For anyone experiencing anaphylaxis, epinephrine should be given right away followed by a call to 911 for further treatment and transfer to a hospital. The main medicine to treat anaphylaxis is epinephrine. This is a medicine given by an injection. The best place to inject it is in the muscles of the outer part of the thigh. If the symptoms do not improve very quickly, the injection should be given again in 5 to 30 minutes.